Animal and human studies showed its beneficial effects on neurodegenerative diseases. #B ICONICAL ANISHA SHORTER FREE#Resveratrol in grape, can effectively fight against free radicals and inflammatory chains. Polyphenolic and non-polyphenolic compounds available in grape, can correspondingly play an antioxidative role and protect against these substances (Fodor et al., 2018 ▶ Sheng et al, 2018 ▶ Shukitt-Hale et al., 2005 ▶). To neutralize ROS, the body needs antioxidants. During the development of diseases, reactive oxygen species (ROS) are also created and they can trigger a chain of destructive reactions that damage cell membranes such as the membrane of neurons. Moreover, neurodegenerative diseases, chronic cardiovascular diseases, cancer, and inflammatory diseases can be considered direct results of oxidative stress. Nowadays, the importance of such compounds for body health and disease prevention is highlighted. The beneficial effects of grapes and its relevant products such as grape juice, grape seed extract, and dried grape might be associated with their bioactive phytochemicals including polyphenolic compounds (flavonoids, anthocyanins, resveratrol), tannins (proanthocyanidins), alkaloid compounds (indolamine, melatonin, and serotonin), furfural (a carbohydrate), boron, iron, potassium, calcium, and vitamins ( Iriti and Faoro, 2009 ▶ Iriti and Faoro, 2006 ▶ Iriti et al., 2006 ▶). Therefore, regular consumption of grapes and its related products can improve memory and play a very important role against neurodegenerative diseases such as Alzheimer’s disease (AD), cancer, cardiovascular diseases, platelet aggregation, atherosclerosis, blood pressure, viral infections, wound and pain (Keservani et al., 2016 ▶ Emami et al., 2010 ▶ Krikorian et al. ) are endowed with beneficial nutraceutical values for the brain and cognitive processes. Moreover, evidence has been provided that some fruits such as grapes ( Vitis vinifera L. In this respect, a group of foods or part of them with disease prevention and treatment effects are known as nutraceuticals. The processes of cognition and correct brain activity are unquestionably related to proper nutrition. Cognition refers to a group of brain processes that can be defined by means of concepts such as intelligence, memory, and mood (Pribis and Shukitt-Hale, 2014 ▶).
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